The gene view histogram is a graphical view of mutations across HMGCR. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left.

GENCODE basic,

APPRIS P1: Transcript(s) expected to code for the main functional isoform based solely on the core modules in the APPRIS.

APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene.

APPRIS P1, Hmgcr-209

Proteomics products related to HMGCR Gene Other products related to HMGCR such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com genomics-online.com Variants in the HMGCR gene region, which represent proxies for statin treatment, were associated with overall cancer risk (odds ratio [OR] per one standard deviation decrease in low-density lipoprotein [LDL] cholesterol 0.76, 95% confidence interval [CI] 0.65–0.88, p=0.0003) but variants in gene regions representing alternative lipid-lowering treatment targets (PCSK9, LDLR, NPC1L1, APOC3 18 Sep 2012 In mammalian genomes, only one gene encodes the HMGCR enzyme, which mainly resides in the membrane of the endoplasmic reticulum[19, The first gene implicated in the production or activity of an attractant by the SGPs was hmgcr (columbus), which encodes HMGCoA reductase (Van Doren, 1998). In 26 Mar 2009 To study the role of genetic variation in the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGCR) gene in polycystic ovary HUGO Gene Nomenclature Committee (HGNC) approved gene symbol report for HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) reductase (HMGCR) gene, the rate-limiting enzyme in cho- lesterol biosynthesis, and the target of LDL-C lowering statin drugs. During the preparation of this 15 Oct 2008 and HMG-CoA Reductase Genes by Human ACBP Cholesterol • Gene regulation • HNF-4α • Promoter HMGCS1 and HMGCR gene. Gene Snapshot. HMG Coenzyme A reductase (Hmgcr) encodes the rate- controlling enzyme of the mevalonate pathway that produces isoprenoids. It is required 10 Products Gene ID: Human(3156) Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback 20 Nov 2017 The low-density lipoprotein cholesterol (LDLC)-lowering allele of a variant in the HMGCR gene that encodes the targeted enzyme in statin 5 Mar 2021 HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene. Diseases associated with HMGCR include Familial Species, TM, AA, Chromosomal Location, Gene Symbol, Gene Name, Reference.

Figure 2b presents the comparison of HMGCR muscle and liver expression levels in two groups of Duroc pigs corresponding to the most extreme animals for 13 traits related to growth, HMGCR gene product. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. 2021-01-22 A single nucleotide polymorphism in the 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk) study - Volume 104 Issue 5 Summaries for HMGCR gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL) About This Sectio 2011-01-31 2017-11-20 Gene name. HMGCR : Synonyms. Description. 3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol) Entrez gene summary. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase.

The first gene implicated in the production or activity of an attractant by the SGPs was hmgcr (columbus), which encodes HMGCoA reductase (Van Doren, 1998). In

As in the hamster Hmgcr gene, this upstream region provides sites for statin-dependent induction and sterol-dependent suppression. Gene: Hmgcr - ENSMUSG00000021670 - Mus musculus (mouse) General information. Ensembl ID: ENSMUSG00000021670: Name: Hmgcr: Description Symbol Description Category GIFtS GC id Score; 1: HMGCR: 3-Hydroxy-3-Methylglutaryl-CoA Reductase: Protein Coding: 47: GC05P075336: 47.16: 2: PRKAA2: Protein Kinase AMP-Activated Catalytic Subunit Alpha 2 Searching the mammalian genome databases with the protein sequence of human HMGCR revealed only a single HMGCR gene in all three genomes, i.e., only a single gene with a statistically significant similarity to the catalytic domain of HMGCR (TBLASTN E-score < 0.001). The human gene is localized at 5q13.3-q14.3 and the rodent homologs are found Previous studies in cultured cells (Schumacher et al., 2015) revealed that UBIAD1 also inhibits endoplasmic reticulum (ER)-associated degradation (ERAD) of ubiquitinated HMG CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway that produces cholesterol and essential nonsterol isoprenoids.

However, gene encoding HMGCR remains unchanged regardless of the type of dietary feeding assays. All these results indicate that the change in the expression of the HMGCR protein during the cholesterol and lovastatin feeding is a result of sterol-mediated modulation of its degradation.

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Hmgcr Addgene Alerts Receive email alerts when new plasmids with this gene become available. We investigated rs12916 in the HMGCR gene as an instrument for HMGCR inhibition by statins as has been done in prior studies of diabetes 31 and prostate cancer, 22 based on rs12916 being the lead SNP in this locus in relation to LDLC levels. 38, HMGCR rs12916 and cancer risk was analysed by Cox regression with attained age as time-scale, and the SNP as a continuous 0,1,2 (CC, CT, TT) variable. KJ891361 - Synthetic construct Homo sapiens clone ccsbBroadEn_00755 HMGCR gene, encodes complete protein. AK312437 - Homo sapiens cDNA, FLJ92784, highly similar to Homo sapiens 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR), mRNA. LF332352 - JP 2014500723-A/139855: Polycomb-Associated Non-Coding RNAs.
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The present work provides evidence to support the association of promoter DNA methylation status with the risk profile of CHD. Our data indicates that promoter DNA hypermethylation of the ABCG1 and GALNT2 genes, but not the HMGCR gene, is associated with an increased risk of CHD. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the p Search external sites for HMGCR Gene information about ENSG00000113161 / HMGCR - 3-hydroxy-3-methylglutaryl-CoA reductase We also investigated cancer risk for a SNP (rs12916) in the gene encoding hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the targeted enzyme in statin treatment. We used logistic regression and SNP pleiotropy-adjusted analyses to estimate the odds ratio per standard deviation (OR). Gene ID: Human(3156) Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase.

As in the hamster Hmgcr gene, this upstream region provides sites for statin-dependent induction and sterol-dependent suppression. Peroxisomal HMGCR might be coded by a second gene, but is not detected because it is more than 35% different from the ER enzyme. This is confuted by the fact that peroxisomal HMGCR is recognized not only in the catalytic domain but also at epitopes in the membrane-spanning region by several of the same antibodies as the ER enzyme. Hmgcr: Description: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Source:MGI Symbol;Acc:MGI:96159] Organism: Mus musculus: Synonym(s) 3-hydroxy-3-methylglutaryl-coa reductase, g3x8u5, hmg-coar, q5u4i2, red: Orthologs(s) 24 orthologs The Function of HMGCR Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
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24 Aug 2010 methylglutaryl coenzyme A reductase (HMGCR), is required for the generation genes and pathways in tumor development and progression.

We aim to study the role of the obesity-linked gene and statin target HMGCR in endocrine, neuronal and muscular functions. We discovered CDK5RAP2 gene and tau pathophysiology in late-onset sporadic Alzheimer's RISK VARIANTS FOR ALZHEIMER'S DISEASE IN THE HMGCR GENE LOCUS. Seven predicted target genes for the downregulated microRNAs were annotated factor receptor (EGFR), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), Nytt antigen i myosit-antikroppspanelen – antikroppar mot HMGCR. Från och MDA5 (melanoma differentiation-associated gene 5).

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We aim to study the effect of statins on adipocyte insulin resistance and the impact of genetic modification of the HMGCR gene on adipocyte function.

Alternate Names: 3156 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE HMGCR LDLCQ3 142910 5006 2012-09-18 · The gene encoding HMGCR uses alternative, mutually exclusive exon 1 sequences. This contributes to an increased complexity of HMGCR transcripts. Further studies are needed to investigate whether HMGCR splice variants identified in this study are physiologically functional. HMGCR_ENST00000511206 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, HMGCR_ENST00000511206 Genome Browser, HMGCR_ENST00000511206 References HMGCR_ENST00000511206 - Explore an overview of HMGCR_ENST00000511206, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data. Description of HMGCR CRISPR guide RNA. Search for other guide RNAs .